PDB entry 2cke

View 2cke on RCSB PDB site
Description: human death-associated drp-1 kinase in complex with inhibitor
Class: transferase/inhibitor
Keywords: transferase-inhibitor complex, calmodulin-binding, nucleotide-binding, serine/threonine-protein kinase, apoptosis
Deposited on 2006-04-18, released 2007-05-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.206
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Death-associated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIK4 (1-End)
      • conflict (231)
      • conflict (243)
    Domains in SCOPe 2.05: d2ckea_
  • Chain 'B':
    Compound: Death-associated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIK4
      • conflict (231)
      • conflict (243)
    Domains in SCOPe 2.05: d2ckeb_
  • Chain 'C':
    Compound: Death-associated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIK4
      • conflict (231)
      • conflict (243)
    Domains in SCOPe 2.05: d2ckec_
  • Chain 'D':
    Compound: Death-associated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIK4
      • conflict (231)
      • conflict (243)
    Domains in SCOPe 2.05: d2cked_
  • Heterogens: IQU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ckeA (A:)
gmepfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsre
eierevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsf
ikqildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifg
tpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdee
ffshtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkq
yvrrrwklsfsivslcnhltr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ckeA (A:)
mepfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsree
ierevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsfi
kqildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifgt
pefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdeef
fshtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkqy
v

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ckeB (B:)
gmepfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsre
eierevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsf
ikqildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifg
tpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdee
ffshtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkq
yvrrrwklsfsivslcnhltr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ckeB (B:)
epfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsreei
erevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsfik
qildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifgtp
efvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdeeff
shtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkqyv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ckeC (C:)
gmepfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsre
eierevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsf
ikqildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifg
tpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdee
ffshtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkq
yvrrrwklsfsivslcnhltr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ckeC (C:)
epfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsreei
erevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsfik
qildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifgtp
efvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdeeff
shtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkqyv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ckeD (D:)
gmepfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsre
eierevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsf
ikqildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifg
tpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdee
ffshtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkq
yvrrrwklsfsivslcnhltr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ckeD (D:)
epfkqqkvedfydigeelgsgqfaivkkcrekstgleyaakfikkrqsrasrrgvsreei
erevsilrqvlhhnvitlhdvyenrtdvvlilelvsggelfdflaqkeslseeeatsfik
qildgvnylhtkkiahfdlkpenimlldknipiphiklidfglaheiedgvefknifgtp
efvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanitsvsydfdeeff
shtselakdfirkllvketrkrltiqealrhpwitpvdnqqamvrresvvnlenfrkqyv