PDB entry 2cjz

View 2cjz on RCSB PDB site
Description: crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine
Class: hydrolase
Keywords: protein phosphatase, step, ptpn5, hydrolase, phosphatase
Deposited on 2006-04-10, released 2006-05-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-06-20, with a file datestamp of 2012-06-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.177
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: human protein tyrosine phosphatase ptpn5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CJZ (Start-22)
      • variant see remark 99 (54)
      • variant see remark 99 (63-64)
      • engineered mutation (237)
      • variant see remark 99 (282)
    • Uniprot P54829 (23-End)
    Domains in SCOPe 2.04: d2cjza_
  • Heterogens: PTR, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cjzA (A:)
mhhhhhhssgvdlgtenlyfqsmsrvlqaeelhekaldpfllqaeffeipmnfvdpkeyd
ipglvrknryktilpnphsrvcltspdpddplssyinanyirgyggeekvyiatqgpivs
tvadfwrmvwqehtpiivmitnieemnekcteywpeeqvaydgveitvqkvihtedyrlr
lislksgteerglkhywftswpdqktpdrappllhlvreveeaaqqegphcapiivhssa
gigrtgcfiatsiccqqlrqegvvdilkttcqlrqdrggmiqtceqyqfvhhvmslyekq
lshqs

    Sequence, based on observed residues (ATOM records): (download) 
    >2cjzA (A:)
nlyfqsmsrvlqaeelhekaldpfllqaeffeipmnfvdpkeydipglvrknryktilpn
phsrvcltspdpddplssyinanyirgyggeekvyiatqgpivstvadfwrmvwqehtpi
ivmitteywpeeqvaydgveitvqkvihtedyrlrlislkseerglkhywftswpdqktp
drappllhlvreveeaaqqegphcapiivhssagigrtgcfiatsiccqqlrqegvvdil
kttcqlrqdrggmiqtceqyqfvhhvmslyekqls