PDB entry 2cjt

View 2cjt on RCSB PDB site
Description: structural basis for a munc13-1 dimeric - munc13-1 - rim heterodimer switch: c2-domains as versatile protein-protein interaction modules
Class: exocytosis
Keywords: phorbol-ester binding, neurotransmitter release, rim, munc13, c2 domains, exocytosis, metal-binding, protein-protein interactions, zinc finger, synaptosome
Deposited on 2006-04-06, released 2006-06-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-09-28, with a file datestamp of 2011-09-23.
Experiment type: XRAY
Resolution: 1.44 Å
R-factor: 0.16
AEROSPACI score: 0.67 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: unc-13 homolog a
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CJT (0-2)
    • Uniprot Q62768 (3-130)
    Domains in SCOPe 2.07: d2cjta1
  • Chain 'B':
    Compound: unc-13 homolog a
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CJT (0-2)
    • Uniprot Q62768 (3-130)
    Domains in SCOPe 2.07: d2cjtb_
  • Chain 'C':
    Compound: unc-13 homolog a
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CJT
    • Uniprot Q62768 (Start-130)
    Domains in SCOPe 2.07: d2cjtc_
  • Chain 'D':
    Compound: unc-13 homolog a
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CJT
    • Uniprot Q62768 (Start-130)
    Domains in SCOPe 2.07: d2cjtd_
  • Heterogens: EDO, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cjtA (A:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdpt
fhrilldahfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2cjtA (A:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsgtkdptfhrilldahf
e

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2cjtB (B:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdpt
fhrilldahfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2cjtB (B:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsgtkdptfhrilldahf
e

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2cjtC (C:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdpt
fhrilldahfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2cjtC (C:)
sllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrldlglt
vevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdptfhri
lldahfe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2cjtD (D:)
ggvmsllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrld
lgltvevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdpt
fhrilldahfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2cjtD (D:)
sllcvgvkkakfdgaqekfntyvtlkvqnvksttiavrgsqpsweqdfmfeinrldlglt
vevwnkgliwdtmvgtvwiplrtirqsneegpgewltldsqaimadseicgtkdptfhri
lldahfe