PDB entry 2cem

View 2cem on RCSB PDB site
Description: p1' extended hiv-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold
Class: hydrolase
Keywords: hiv-1, protease, inhibitor, aspartyl protease, hydrolase
Deposited on 2006-02-08, released 2007-02-13
The last revision prior to the SCOP 1.73 freeze date was dated 2007-02-13, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.252
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: pol protein
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8Q3H0
  Domains in SCOP 1.73: d2cema1
• Chain 'B':
  Compound: pol protein
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8Q3H0 (0-98)
  Domains in SCOP 1.73: d2cemb1
• Heterogens: 2AH, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2cemA (A:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2cemB (B:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf