PDB entry 2cbt

View 2cbt on RCSB PDB site
Description: crystal structure of the neocarzinostatin 4tes1 mutant bound testosterone hemisuccinate.
Class: antibiotic
Keywords: antibiotic, phage-display, hapten binding, neocarzinostatin, antimicrobial, DNA-binding
Deposited on 2006-01-06, released 2006-03-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.218
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: neocarzinostatin
    Species: STREPTOMYCES CARZINOSTATICUS [TaxId:1897]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A3R9
      • engineered mutation (32)
      • engineered mutation (34)
      • engineered mutation (36)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (51)
      • engineered mutation (77)
      • engineered mutation (93)
      • engineered mutation (95)
      • engineered mutation (97)
      • engineered mutation (100-101)
    Domains in SCOPe 2.06: d2cbta_
  • Chain 'B':
    Compound: neocarzinostatin
    Species: STREPTOMYCES CARZINOSTATICUS [TaxId:1897]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A3R9 (Start-111)
      • engineered mutation (32)
      • engineered mutation (34)
      • engineered mutation (36)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (51)
      • engineered mutation (77)
      • engineered mutation (93)
      • engineered mutation (95)
      • engineered mutation (97)
      • engineered mutation (100-101)
    Domains in SCOPe 2.06: d2cbtb_
  • Heterogens: TH2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cbtA (A:)
aaptatvtpssglsdgtvvkvagaglqagtaywvaqsawvdtgvyasnpadissvtadan
gsastsltvrrsfegflwdgtrwgtvdcttaachvtlrdalsngpegvaisf

    Sequence, based on observed residues (ATOM records): (download) 
    >2cbtA (A:)
aptatvtpssglsdgtvvkvagaglqagtaywvaqsawvdtgvyasnpadissvtadang
sastsltvrrsfegflwdgtrwgtvdcttaachvtlrdalsngpegvaisf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2cbtB (B:)
aaptatvtpssglsdgtvvkvagaglqagtaywvaqsawvdtgvyasnpadissvtadan
gsastsltvrrsfegflwdgtrwgtvdcttaachvtlrdalsngpegvaisf

    Sequence, based on observed residues (ATOM records): (download) 
    >2cbtB (B:)
aptatvtpssglsdgtvvkvagaglqagtaywvaqsawvdtgvyasnpadissvtadang
sastsltvrrsfegflwdgtrwgtvdcttaachvtlrdalsngpegvaisf