PDB entry 2car

View 2car on RCSB PDB site
Description: crystal structure of human inosine triphosphatase
Class: hydrolase
Keywords: hydrolase, inosine triphosphate pyrophosphohydrolase, inosine triphosphatase deficiency, itp, imp, disease mutation, nucleotide metabolism
Deposited on 2005-12-22, released 2006-01-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.09 Å
R-factor: 0.0974
AEROSPACI score: 0.95 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CAR (0-1)
    • Uniprot Q9BY32 (2-195)
    Domains in SCOPe 2.07: d2cara1
  • Chain 'B':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CAR
    • Uniprot Q9BY32 (2-195)
    Domains in SCOPe 2.07: d2carb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2carA (A:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2carB (B:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2carB (B:)
    maaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqea
    vrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfal
    stgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrfr
    allelqeyfgslaa