PDB entry 2c7v

View 2c7v on RCSB PDB site
Description: Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate
Class: oxidoreductase
Keywords: pteridine reductase, trypanosomatids, drug resistance, short-chain dehydrogenase/reductase, methotrexate resistance, oxidoreductase
Deposited on 2005-11-29, released 2006-09-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pteridine reductase
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c7va_
  • Chain 'B':
    Compound: pteridine reductase
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c7vb_
  • Chain 'C':
    Compound: pteridine reductase
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c7vc_
  • Chain 'D':
    Compound: pteridine reductase
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c7vd_
  • Heterogens: NAP, MTX, NI, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c7vA (A:)
meapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcq
adltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqv
aeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkha
lvgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiada
viflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >2c7vA (A:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgktvetqvaeligtnai
apflltmsfaqrqkgssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapy
girvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgs
iikvdgglslvha

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c7vB (B:)
meapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcq
adltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqv
aeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkha
lvgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiada
viflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >2c7vB (B:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqngktvetqvaeligtna
iapflltmsfaqrqktssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelap
ygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitg
siikvdgglslvha

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2c7vC (C:)
meapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcq
adltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqv
aeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkha
lvgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiada
viflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >2c7vC (C:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqggktvetqvaeligtna
iapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhalvgltqsa
alelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgs
aqyitgsiikvdgglslvha

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2c7vD (D:)
meapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcq
adltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqv
aeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkha
lvgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiada
viflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >2c7vD (D:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhngktvetqvaelig
tnaiapflltmsfaqrqkgssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaale
lapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqy
itgsiikvdgglslvha