PDB entry 2c5n

View 2c5n on RCSB PDB site
Description: Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Class: transferase
Keywords: differential inhibition, transferase, cdk2, ATP-binding, cell cycle, cell division, polymorphism, phosphorylation, nucleotide-binding, serine/threonine-protein, kinase, mitosis, cyclin
Deposited on 2005-10-30, released 2006-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c5na_
  • Chain 'B':
    Compound: cyclin a2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c5nb1, d2c5nb2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c5nc_
  • Chain 'D':
    Compound: cyclin a2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c5nd1, d2c5nd2
  • Heterogens: CK8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c5nA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5nA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c5nB (B:)
evpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlh
lavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlr
mehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylps
viagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsireky
knskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5nB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2c5nC (C:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5nC (C:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2c5nD (D:)
evpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlh
lavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlr
mehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylps
viagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsireky
knskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5nD (D:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl