PDB entry 2c5l

View 2c5l on RCSB PDB site
Description: structure of plc epsilon ras association domain with hras
Class: signaling protein/complex
Keywords: ras, ubiquitin superfold, oncogene, GTP-binding, nucleotide-binding, signaling protein, disease mutation, lipoprotein, palmitate, prenylation, proto-oncogene
Deposited on 2005-10-27, released 2006-02-20
The last revision prior to the SCOP 1.75 freeze date was dated 2006-02-20, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.187
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (18)
    • Uniprot P01112 (7-172)
    Domains in SCOP 1.75: d2c5la1
  • Chain 'B':
    Compound: gtpase hras
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (18)
    • Uniprot P01112 (7-172)
    Domains in SCOP 1.75: d2c5lb1
  • Chain 'C':
    Compound: phosphoinositide-specific phospholipase c plc-epsilon
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c5lc1
  • Chain 'D':
    Compound: phosphoinositide-specific phospholipase c plc-epsilon
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c5ld1
  • Heterogens: MG, GTP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c5lA (A:)
gggsggsmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetcll
dildtagqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvl
vgnkcdlaartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lA (A:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c5lB (B:)
gggsggsmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetcll
dildtagqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvl
vgnkcdlaartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lB (B:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2c5lC (C:)
gsseeesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvl
leevvkdttnkktttpkssqrvlldqecvfqaqskwkgagkfilklkeqvqasredk

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lC (C:)
eesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvlleev
vkdkssqrvlldqecvfqaqskwkgagkfilklkeqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2c5lD (D:)
gsseeesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvl
leevvkdttnkktttpkssqrvlldqecvfqaqskwkgagkfilklkeqvqasredk

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lD (D:)
eesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvlleev
sqrvlldqecvfkfilklkeq