PDB entry 2c5l

View 2c5l on RCSB PDB site
Description: Structure of PLC epsilon Ras association domain with hRas
Class: signaling protein
Keywords: signaling protein-complex, ras, ubiquitin superfold, oncogene, GTP-binding, nucleotide- binding, signaling protein, disease mutation, lipoprotein, palmitate, prenylation, proto-oncogene
Deposited on 2005-10-27, released 2006-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (18)
    • Uniprot P01112 (7-172)
    Domains in SCOPe 2.08: d2c5la_
  • Chain 'B':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (18)
    • Uniprot P01112 (7-172)
    Domains in SCOPe 2.08: d2c5lb_
  • Chain 'C':
    Compound: phosphoinositide-specific phospholipase c plc-epsilon
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (46)
    • Uniprot Q9HBX6
    Domains in SCOPe 2.08: d2c5lc1
  • Chain 'D':
    Compound: phosphoinositide-specific phospholipase c plc-epsilon
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C5L
      • engineered mutation (46)
    • Uniprot Q9HBX6
    Domains in SCOPe 2.08: d2c5ld_
  • Heterogens: GTP, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c5lA (A:)
gggsggsmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetcll
dildtagqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvl
vgnkcdlaartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lA (A:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c5lB (B:)
gggsggsmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetcll
dildtagqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvl
vgnkcdlaartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lB (B:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2c5lC (C:)
gsseeesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvl
leevvkdttnkktttpkssqrvlldqecvfqaqskwkgagkfilklkeqvqasredk

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lC (C:)
eesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvlleev
vkdkssqrvlldqecvfqaqskwkgagkfilklkeqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2c5lD (D:)
gsseeesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvl
leevvkdttnkktttpkssqrvlldqecvfqaqskwkgagkfilklkeqvqasredk

    Sequence, based on observed residues (ATOM records): (download) 
    >2c5lD (D:)
eesffvqvhdvspeqprtvikaprvstaqdviqqtlckakyslsilsnpnpsdyvlleev
sqrvlldqecvfkfilklkeq