PDB entry 2c2x

View 2c2x on RCSB PDB site
Description: three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from mycobacterium tuberculosis
Class: oxidoreductase
Keywords: tetrahydrofolate, nadp, methylenetetrahydrofolate dehydrogenase, cyclohydrolase, hydrolase, oxidoreductase, psi, protein structure initiative, tb structural genomics consortium, tbsgc
Deposited on 2005-09-30, released 2005-10-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.208
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C2X
    • Uniprot O50385 (1-280)
    Domains in SCOPe 2.06: d2c2xa1, d2c2xa2
  • Chain 'B':
    Compound: methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C2X
    • Uniprot O50385 (1-280)
    Domains in SCOPe 2.06: d2c2xb1, d2c2xb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c2xA (A:)
vgaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakv
gitsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdad
glhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltr
rsenatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddgl
vgdvhpdvwelaghvspnpggvgpltraflltnvvelaerr

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2xA (A:)
gaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakvg
itsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdadg
lhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltrr
senatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddglv
gdvhpdvwelaghvspnpggvgpltraflltnvvelaerr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c2xB (B:)
vgaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakv
gitsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdad
glhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltr
rsenatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddgl
vgdvhpdvwelaghvspnpggvgpltraflltnvvelaerr

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2xB (B:)
gaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakvg
itsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdadg
lhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltrr
senatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddglv
gdvhpdvwelaghvspnpggvgpltraflltnvvelaerr