PDB entry 2c2v

View 2c2v on RCSB PDB site
Description: Crystal structure of the CHIP-UBC13-UEV1a complex
Class: chaperone
Keywords: chaperone, heat-shock protein complex, e3 ligase, ubiquitinylation, tpr, heat-shock protein
Deposited on 2005-09-30, released 2005-11-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-15, with a file datestamp of 2019-05-10.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61088 (3-153)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d2c2vb2, d2c2vb3
  • Chain 'C':
    Compound: Ubiquitin-conjugating enzyme E2 variant 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13404 (0-141)
      • conflict (47)
    Domains in SCOPe 2.08: d2c2vc1
  • Chain 'E':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c2ve_
  • Chain 'F':
    Compound: Ubiquitin-conjugating enzyme E2 variant 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13404 (Start-141)
      • conflict (47)
    Domains in SCOPe 2.08: d2c2vf_
  • Chain 'H':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2c2vh_
  • Chain 'I':
    Compound: Ubiquitin-conjugating enzyme E2 variant 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13404 (Start-141)
      • conflict (47)
    Domains in SCOPe 2.08: d2c2vi_
  • Chain 'K':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61088 (3-153)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d2c2vk2, d2c2vk3
  • Chain 'L':
    Compound: Ubiquitin-conjugating enzyme E2 variant 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13404 (Start-141)
      • conflict (47)
    Domains in SCOPe 2.08: d2c2vl_
  • Chain 'S':
    Compound: STIP1 homology and U box-containing protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Stub1, Chip
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WUD1 (0-End)
      • conflict (42)
    Domains in SCOPe 2.08: d2c2vs1
  • Chain 'T':
    Compound: STIP1 homology and U box-containing protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Stub1, Chip
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WUD1 (0-77)
      • conflict (42)
    Domains in SCOPe 2.08: d2c2vt_
  • Chain 'U':
    Compound: STIP1 homology and U box-containing protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Stub1, Chip
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WUD1 (0-End)
      • conflict (42)
    Domains in SCOPe 2.08: d2c2vu_
  • Chain 'V':
    Compound: STIP1 homology and U box-containing protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Stub1, Chip
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WUD1
      • conflict (42)
    Domains in SCOPe 2.08: d2c2vv_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c2vB (B:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dplandvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vB (B:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dpndvaeqwktneaqaietarawtrlyamnni

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2c2vC (C:)
ttgvkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriy
slkiecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelr
rlmmskenmklpqppegqcysn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2c2vE (E:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dplandvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vE (E:)
aglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpee
ypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpddpn
dvaeqwktneaqaietarawtrlyamnni

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2c2vF (F:)
ttgvkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriy
slkiecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelr
rlmmskenmklpqppegqcysn

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vF (F:)
vkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriyslk
iecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelrrlm
mskenmklpqppegqcysn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2c2vH (H:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dplandvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vH (H:)
aglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpee
ypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpddpn
dvaeqwktneaqaietarawtrlyamnni

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2c2vI (I:)
ttgvkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriy
slkiecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelr
rlmmskenmklpqppegqcysn

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vI (I:)
vkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriyslk
iecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelrrlm
mskenmklpqppegqcysn

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >2c2vK (K:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dplandvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vK (K:)
agsaglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelfl
peeypmaapkvrfmtkiyhpnvdklgricldilkdkwspalqirtvllsiqallsapnpd
dpndvaeqwktneaqaietarawtrlyamnni

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2c2vL (L:)
ttgvkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriy
slkiecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelr
rlmmskenmklpqppegqcysn

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vL (L:)
vkvprnfrlleeleegqkgvgdgtvswgleddedmtltrwtgmilgpprtiyenriyslk
iecgpkypeappfvrfvtkinmngvnssngvvdpraisvlakwqnsysikvvlqelrrlm
mskenmklpqppegqcysn

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >2c2vS (S:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafisengwvedy

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vS (S:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafisengwv

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2c2vT (T:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafisengwvedy

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >2c2vU (U:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafisengwvedy

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vU (U:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafiseng

  • Chain 'V':
    Sequence, based on SEQRES records: (download) 
    >2c2vV (V:)
dipdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnla
mkevidafisengwvedy

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2vV (V:)
pdylcgkisfelmrepcitpsgitydrkdieehlqrvghfnpvtrspltqeqlipnlamk
evidafiseng