PDB entry 2c2t

View 2c2t on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
Class: oxidoreductase
Keywords: nonclassical antifolates, lipophilic antifolates, nadp, one-carbon metabolism, oxidoreductase, reductase
Deposited on 2005-09-30, released 2007-04-10
The last revision prior to the SCOP 1.75 freeze date was dated 2007-07-17, with a file datestamp of 2007-07-13.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.16
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c2ta1
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c2tb1
  • Heterogens: NDP, 39B, 39E, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2c2tA (A:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2c2tB (B:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd