PDB entry 2c2s

View 2c2s on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
Class: oxidoreductase
Keywords: nonclassical antifolates, lipophilic antifolates, nadp, one-carbon metabolism, oxidoreductase, reductase
Deposited on 2005-09-29, released 2007-04-10
The last revision prior to the SCOP 1.75 freeze date was dated 2007-07-17, with a file datestamp of 2007-07-13.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.157
AEROSPACI score: 0.84 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c2sa1
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c2sb1
  • Heterogens: NDP, 34B, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2c2sA (A:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2c2sB (B:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd