PDB entry 2c18

View 2c18 on RCSB PDB site
Description: 5-(4-carboxy-2-oxo-butane-1-sulfonyl)-4-oxo-pentanoic acid bound to porphobilinogen synthase from pseudomonas aeruginosa
Class: lyase
Keywords: enzyme mechanism, metalloenzyme, porphobilinogen synthase, cocrystallization, lyase, porphyrin biosynthesis
Deposited on 2005-09-11, released 2006-06-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: 0.151
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: delta-aminolevulinic acid dehydratase
    Species: Pseudomonas aeruginosa [TaxId:287]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q59643
      • conflict (198)
    Domains in SCOPe 2.06: d2c18a_
  • Chain 'B':
    Compound: delta-aminolevulinic acid dehydratase
    Species: Pseudomonas aeruginosa [TaxId:287]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q59643
      • conflict (198)
    Domains in SCOPe 2.06: d2c18b_
  • Heterogens: MG, NA, CL, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c18A (A:)
msftpanraypytrlrrnrrddfsrrlvrenvltvddlilpvfvldgvnqresipsmpgv
erlsidqllieaeewvalgipalalfpvtpvekksldaaeaynpegiaqratralrerfp
elgiitdvaldpftthgqdgildddgyvlndvsidvlvrqalshaeagaqvvapsdmmdg
rigairealesaghtnvrvmaysakyasayygpfrdavgsasnlgkgnkatyqmdpansd
ealhevaadlaegadmvmvxpgmpyldivrrvkdefraptfvyqvsgeyamhmgaiqngw
laesvilesltafkragadgiltyfakqaaeqlrrgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2c18A (A:)
ftpanraypytrlrrnrrddfsrrlvrenvltvddlilpvfvldgvnqresipsmpgver
lsidqllieaeewvalgipalalfpvtpvekksldaaeaynpegiaqratralrerfpel
giitdvaldpftthgqdgildddgyvlndvsidvlvrqalshaeagaqvvapsdmmdgri
gairealesaghtnvrvmaysakyasayygpfrdavgsasnlgkgnkatyqmdpansdea
lhevaadlaegadmvmvxpgmpyldivrrvkdefraptfvyqvsgeyamhmgaiqngwla
esvilesltafkragadgiltyfakqaaeqlrrg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c18B (B:)
msftpanraypytrlrrnrrddfsrrlvrenvltvddlilpvfvldgvnqresipsmpgv
erlsidqllieaeewvalgipalalfpvtpvekksldaaeaynpegiaqratralrerfp
elgiitdvaldpftthgqdgildddgyvlndvsidvlvrqalshaeagaqvvapsdmmdg
rigairealesaghtnvrvmaysakyasayygpfrdavgsasnlgkgnkatyqmdpansd
ealhevaadlaegadmvmvxpgmpyldivrrvkdefraptfvyqvsgeyamhmgaiqngw
laesvilesltafkragadgiltyfakqaaeqlrrgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2c18B (B:)
sftpanraypytrlrrnrrddfsrrlvrenvltvddlilpvfvldgvnqresipsmpgve
rlsidqllieaeewvalgipalalfpvtpvekksldaaeaynpegiaqratralrerfpe
lgiitdvaldpftthgqdgildddgyvlndvsidvlvrqalshaeagaqvvapsdmmdgr
igairealesaghtnvrvmaysakyasayygpfrdavgsankatyqmdpansdealheva
adlaegadmvmvxpgmpyldivrrvkdefraptfvyqvsgeyamhmgaiqngwlaesvil
esltafkragadgiltyfakqaaeqlrrg