PDB entry 2c0o

View 2c0o on RCSB PDB site
Description: Src family kinase Hck with bound inhibitor A-770041
Class: transferase
Keywords: tyrosine-protein kinase, transferase, ATP-binding, kinase, lipoprotein, myristate, nucleotide-binding, palmitate, phosphorylation, sh2 domain, sh3 domain
Deposited on 2005-09-06, released 2006-09-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C0O (Start-7)
      • engineered mutation (450-452)
    • Uniprot P08631 (8-453)
    Domains in SCOPe 2.08: d2c0oa1, d2c0oa2, d2c0oa3, d2c0oa4
  • Chain 'B':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C0O (Start-7)
      • engineered mutation (450-452)
    • Uniprot P08631 (8-453)
    Domains in SCOPe 2.08: d2c0ob1, d2c0ob2, d2c0ob3, d2c0ob4
  • Heterogens: L2G, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c0oA (A:)
gamgsgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsny
varvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqg
dtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwek
daweipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktl
qhdklvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafi
eqrnyihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfg
sftiksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmr
cwknrpeerptfeyiqsvlddfytatesqyeeip

    Sequence, based on observed residues (ATOM records): (download) 
    >2c0oA (A:)
riivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
eteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhyk
irtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwekdaweipr
eslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktlqhdklvk
lhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafieqrnyih
rdlraanilvsaslvckiadfglarvipikwtapeainfgsftiksdvwsfgillmeivt
ygripypgmsnpeviralergyrmprpencpeelynimmrcwknrpeerptfeyiqsvld
dfytatesqyeeip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c0oB (B:)
gamgsgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsny
varvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqg
dtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwek
daweipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktl
qhdklvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafi
eqrnyihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfg
sftiksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmr
cwknrpeerptfeyiqsvlddfytatesqyeeip

    Sequence, based on observed residues (ATOM records): (download) 
    >2c0oB (B:)
riivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
eteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhyk
irtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwekdaweipr
eslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktlqhdklvk
lhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafieqrnyih
rdlraanilvsaslvckiadfglarvipikwtapeainfgsftiksdvwsfgillmeivt
ygripypgmsnpeviralergyrmprpencpeelynimmrcwknrpeerptfeyiqsvld
dfytatesqyeeip