PDB entry 2c0i

View 2c0i on RCSB PDB site
Description: src family kinase hck with bound inhibitor a-420983
Class: transferase
Keywords: tyrosine-protein kinase, transferase, ATP-binding, kinase, lipoprotein, myristate, nucleotide-binding, palmitate, phosphorylation, sh2 domain, sh3 domain
Deposited on 2005-09-03, released 2006-09-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.224
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C0I (Start-7)
      • engineered mutation (450-452)
    • Uniprot P08631 (8-453)
    Domains in SCOPe 2.05: d2c0ia1, d2c0ia2, d2c0ia3
  • Chain 'B':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C0I (Start-7)
      • engineered mutation (450-452)
    • Uniprot P08631 (8-453)
    Domains in SCOPe 2.05: d2c0ib1, d2c0ib2, d2c0ib3
  • Heterogens: L1G, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c0iA (A:)
gamgsgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsny
varvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqg
dtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwek
daweipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktl
qhdklvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafi
eqrnyihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfg
sftiksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmr
cwknrpeerptfeyiqsvlddfytatesqyeeip

    Sequence, based on observed residues (ATOM records): (download) 
    >2c0iA (A:)
riivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
eteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhyk
irtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwekdaweipr
eslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktlqhdklvk
lhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafieqrnyih
rdlraanilvsaslvckiadfglarvipikwtapeainfgsftiksdvwsfgillmeivt
ygripypgmsnpeviralergyrmprpencpeelynimmrcwknrpeerptfeyiqsvld
dfytatesqyeeip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c0iB (B:)
gamgsgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsny
varvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqg
dtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwek
daweipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktl
qhdklvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafi
eqrnyihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfg
sftiksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmr
cwknrpeerptfeyiqsvlddfytatesqyeeip

    Sequence, based on observed residues (ATOM records): (download) 
    >2c0iB (B:)
riivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
eteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhyk
irtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwekdaweipr
eslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktlqhdklvk
lhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafieqrnyih
rdlraanilvsaslvckiadfglarvipikwtapeainfgsftiksdvwsfgillmeivt
ygripypgmsnpeviralergyrmprpencpeelynimmrcwknrpeerptfeyiqsvld
dfytatesqyeeip