PDB entry 2bzs

View 2bzs on RCSB PDB site
Description: binding of anti-cancer prodrug cb1954 to the activating enzyme nqo2 revealed by the crystal structure of their complex.
Class: oxidoreductase
Keywords: nqo2, cb1954, fad, flavoprotein, metal-binding, oxidoreductase, polymorphism, zinc
Deposited on 2005-08-22, released 2005-09-23
The last revision prior to the SCOP 1.73 freeze date was dated 2005-11-30, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19584
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nrh dehydrogenase [quinone] 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bzsa1
  • Chain 'B':
    Compound: nrh dehydrogenase [quinone] 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bzsb1
  • Heterogens: ZN, FAD, CB1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bzsA (A:)
chainaagkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkd
itgtlsnpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkg
wmdrvlcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhg
tlhfcgfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >2bzsA (A:)
agkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtls
npevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvl
cqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcg
fkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bzsB (B:)
chainaagkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkd
itgtlsnpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkg
wmdrvlcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhg
tlhfcgfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >2bzsB (B:)
agkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtls
npevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvl
cqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcg
fkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq