PDB entry 2bzi

View 2bzi on RCSB PDB site
Description: crystal structure of the human pim1 in complex with a ruthenium organometallic ligand ru2
Class: transferase
Keywords: pim1, kinase, cancer, leukemia, nuclear protein, nucleotide-binding, transferase
Deposited on 2005-08-18, released 2005-12-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.218
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: proto-oncogene serine threonine protein kinase pim1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11309
      • engineered mutation (249)
    Domains in SCOPe 2.06: d2bzib_
  • Heterogens: DW2, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bziB (B:)
mllskinslahlraapcndlhatklapgkekeplesqyqvgpllgsggfgsvysgirvsd
nlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvirlldwferpdsfvlil
erpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlhrdikdenilidlnrg
elklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaavwslgillydmvcgdi
pfehdeeiiggqvffrqrvssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqeta
eihlhslspgpsk

    Sequence, based on observed residues (ATOM records): (download) 
    >2bziB (B:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiiggqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh