PDB entry 2bz5

View 2bz5 on RCSB PDB site
Description: Structure-based Discovery of a New Class of Hsp90 Inhibitors
Class: chaperone
Keywords: ATP-binding, chaperone, heat shock, nucleotide-binding, phosphorylation
Deposited on 2005-08-11, released 2005-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heat shock protein hsp90-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07900
      • conflict (61)
    Domains in SCOPe 2.08: d2bz5a_
  • Chain 'B':
    Compound: heat shock protein hsp90-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07900
      • conflict (61)
    Domains in SCOPe 2.08: d2bz5b_
  • Heterogens: AB4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bz5A (A:)
peetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiry
esltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmea
lqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmg
rgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2bz5A (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfveke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bz5B (B:)
peetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiry
esltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmea
lqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmg
rgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2bz5B (B:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfveke