PDB entry 2byl

View 2byl on RCSB PDB site
Description: Structure of ornithine aminotransferase triple mutant Y85I Y55A G320F
Class: transferase
Keywords: transferase, disease mutation, mitochondrion, transit peptide plp-dependent enzyme, pyridoxal phosphate
Deposited on 2005-08-03, released 2005-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-01-30, with a file datestamp of 2013-01-25.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.161
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (54)
      • engineered mutation (84)
      • engineered mutation (319)
    Domains in SCOPe 2.08: d2byla1
  • Chain 'B':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (54)
      • engineered mutation (84)
      • engineered mutation (319)
    Domains in SCOPe 2.08: d2bylb_
  • Chain 'C':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (54)
      • engineered mutation (84)
      • engineered mutation (319)
    Domains in SCOPe 2.08: d2bylc_
  • Heterogens: PLP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bylA (A:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnahplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehfstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2bylA (A:)
gpptsddifereykygahnahplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehfstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bylB (B:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnahplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehfstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2bylB (B:)
gpptsddifereykygahnahplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehfstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2bylC (C:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnahplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehfstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2bylC (C:)
gpptsddifereykygahnahplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehfstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf