PDB entry 2byj

View 2byj on RCSB PDB site
Description: Ornithine aminotransferase mutant Y85I
Class: transferase
Keywords: transferase, disease mutation, transit peptide, mitochondrion, plp-dependent enzyme, polymorphism, pyridoxal phosphate
Deposited on 2005-08-02, released 2005-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d2byja1
  • Chain 'B':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d2byjb_
  • Chain 'C':
    Compound: ornithine aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04181 (Start-438)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d2byjc_
  • Heterogens: PLP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2byjA (A:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnyhplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehgstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2byjA (A:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2byjB (B:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnyhplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehgstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2byjB (B:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2byjC (C:)
mfsklahlqrfavlsrgvhssvasatsvatkktvqgpptsddifereykygahnyhplpv
alergkgiylwdvegrkyfdflssisavnqghchpkivnalksqvdkltltsrafynnvl
geyeeyitklfnyhkvlpmntgveagetacklarkwgytvkgiqkykakivfaagnfwgr
tlsaissstdptsydgfgpfmpgfdiipyndlpaleralqdpnvaafmvepiqgeagvvv
pdpgylmgvrelctrhqvlfiadeiqtglartgrwlavdyenvrpdivllgkalsgglyp
vsavlcdddimltikpgehgstyggnplgcrvaiaalevleeenlaenadklgiilrnel
mklpsdvvtavrgkgllnaiviketkdwdawkvclrlrdngllakpthgdiirfapplvi
kedelresieiinktilsf

    Sequence, based on observed residues (ATOM records): (download) 
    >2byjC (C:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssisavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf