PDB entry 2byh
View 2byh on RCSB PDB site
Description: 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the hsp90 molecular chaperone
Class: chaperone
Keywords: pyrazole, hsp90, chaperone, ATP-binding, heat shock, nucleotide-binding, phosphorylation
Deposited on
2005-08-02, released
2005-10-12
The last revision prior to the SCOP 1.75 freeze date was dated
2005-10-26, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.169
AEROSPACI score: 0.6
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heat shock protein hsp90-alpha
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d2byha1 - Heterogens: 2D7, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2byhA (A:)
peetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiry
esltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmea
lqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmg
rgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae
Sequence, based on observed residues (ATOM records): (download)
>2byhA (A:)
pmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskl
dsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadism
igqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhl
kedqteyleerrikeivkkhsqfigypitlfveke