PDB entry 2byh

View 2byh on RCSB PDB site
Description: 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the hsp90 molecular chaperone
Class: chaperone
Keywords: pyrazole, hsp90, chaperone, ATP-binding, heat shock, nucleotide-binding, phosphorylation
Deposited on 2005-08-02, released 2005-10-12
The last revision prior to the SCOP 1.75 freeze date was dated 2005-10-26, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.169
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heat shock protein hsp90-alpha
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2byha1
  • Heterogens: 2D7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2byhA (A:)
peetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiry
esltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmea
lqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmg
rgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2byhA (A:)
pmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskl
dsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadism
igqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhl
kedqteyleerrikeivkkhsqfigypitlfveke