PDB entry 2bxw

View 2bxw on RCSB PDB site
Description: CRYSTAL STRUCTURE OF RHOGDI Lys(135,138,141)Tyr MUTANT
Class: inhibitor
Keywords: inhibitor, crystal engineering, rational surface mutagenesis, gtpase activation
Deposited on 2005-07-27, released 2005-08-19
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-05-30, with a file datestamp of 2012-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.18
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rho GDP-dissociation inhibitor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BXW (Start-2)
      • engineered mutation (71)
      • engineered mutation (74)
      • engineered mutation (77)
    • Uniprot P52565 (3-End)
    Domains in SCOPe 2.05: d2bxwa_
  • Chain 'B':
    Compound: rho GDP-dissociation inhibitor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BXW (Start-2)
      • engineered mutation (71)
      • engineered mutation (74)
      • engineered mutation (77)
    • Uniprot P52565 (3-End)
    Domains in SCOPe 2.05: d2bxwb_
  • Heterogens: FMT, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bxwA (A:)
gamvpnvvvtgltlvcssapgpleldltgdlesfkkqsfvlkegveyrikisfrvnreiv
sgmkyiqhtyrygvyidytdymvgsygpraeeyefltpveeapkgmlargsysiksrftd
ddktdhlswewnltikkdwkd

    Sequence, based on observed residues (ATOM records): (download) 
    >2bxwA (A:)
amvpnvvvtgltlvcssapgpleldltgdlesfkkqsfvlkegveyrikisfrvnreivs
gmkyiqhtyrygvyidytdymvgsygpraeeyefltpveeapkgmlargsysiksrftdd
dktdhlswewnltikkdw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bxwB (B:)
gamvpnvvvtgltlvcssapgpleldltgdlesfkkqsfvlkegveyrikisfrvnreiv
sgmkyiqhtyrygvyidytdymvgsygpraeeyefltpveeapkgmlargsysiksrftd
ddktdhlswewnltikkdwkd

    Sequence, based on observed residues (ATOM records): (download) 
    >2bxwB (B:)
amvpnvvvtgltlvcssapgpleldltgdlesfkkqsfvlkegveyrikisfrvnreivs
gmkyiqhtyrygvyidytdymvgsygpraeeyefltpveeapkgmlargsysiksrftdd
dktdhlswewnltikkdw