PDB entry 2bxv
View 2bxv on RCSB PDB site
Description: dual binding mode of a novel series of dhodh inhibitors
Class: oxidoreductase
Keywords: dihydroorotate dehydrogenase inhibitor, dual binding mode, virtual high-throughput screening, rheumatoid arthritis oxidoreductase
Deposited on
2005-07-27, released
2006-08-16
The last revision prior to the SCOP 1.75 freeze date was dated
2006-08-16, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.203
AEROSPACI score: 0.5
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydroorotate dehydrogenase
Species: Homo sapiens
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d2bxva1 - Heterogens: SO4, ACT, FMN, ORO, 3FT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2bxvA (A:)
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr
Sequence, based on observed residues (ATOM records): (download)
>2bxvA (A:)
matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelg
idglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggv
ssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr