PDB entry 2bxv

View 2bxv on RCSB PDB site
Description: dual binding mode of a novel series of dhodh inhibitors
Class: oxidoreductase
Keywords: dihydroorotate dehydrogenase inhibitor, dual binding mode, virtual high-throughput screening, rheumatoid arthritis oxidoreductase
Deposited on 2005-07-27, released 2006-08-16
The last revision prior to the SCOP 1.73 freeze date was dated 2006-08-16, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.203
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Homo sapiens
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bxva1
  • Heterogens: SO4, ACT, FMN, ORO, 3FT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2bxvA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
    npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
    nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
    vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
    svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
    iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
    igadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bxvA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
    giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
    glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
    vsspntaglgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelg
    idglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggv
    ssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr