PDB entry 2bsm

View 2bsm on RCSB PDB site
Description: Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
Class: chaperone
Keywords: hsp90, ATPase, pu3, chaperone, ATP-binding, heat shock
Deposited on 2005-05-23, released 2005-06-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heat shock protein hsp90-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07900
      • conflict (61)
    Domains in SCOPe 2.08: d2bsma_
  • Heterogens: BSM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bsmA (A:)
peetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiry
esltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmea
lqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmg
rgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2bsmA (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfvek