PDB entry 2blc

View 2blc on RCSB PDB site
Description: SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine
Class: oxidoreductase
Keywords: dihydrofolate reductase, plasmodium vivax, malaria, drug resistance, thymidylate synthase, pyrimethamine, double mutant, oxidoreductase
Deposited on 2005-03-03, released 2005-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-22, with a file datestamp of 2019-05-17.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium vivax [TaxId:5855]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5U9H1 (Start-236)
      • conflict (2)
      • conflict (212)
    • PDB 2BLC (237-237)
    Domains in SCOPe 2.08: d2blca_
  • Heterogens: NDP, CP7, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2blcA (A:)
menlsdvfdiyaicacckvaptsegtknepfsprtfrglgnkgtlpwkcnsvdmkyfrsv
ttyvdeskyeklkwkrerylrmeasqgggdntsggdnthggdnadklqnvvvmgrsnwes
ipkqykplpnrinvvlsktltkedvkekvfiidsiddlllllkklkyykcfiiggaqvyr
eclsrnlikqiyftringaypcdvffpefdesefrvtsvsevynskgttldflvyskv

    Sequence, based on observed residues (ATOM records): (download) 
    >2blcA (A:)
enlsdvfdiyaicacckvaptsegtknepfsprtfrglgnkgtlpwkcnsvdmkyfrsvt
tyvdeskyeklkwkrerylrmeklqnvvvmgrsnwesipkqykplpnrinvvlsktltke
dvkekvfiidsiddlllllkklkyykcfiiggaqvyreclsrnlikqiyftringaypcd
vffpefdesefrvtsvsevynskgttldflvyskv