PDB entry 2bip

View 2bip on RCSB PDB site
Description: human p53 core domain mutant m133l-h168r-v203a-n239y-r249s-n268d
Class: DNA-binding protein
Keywords: 3d-structure, activator, anti-oncogene, apoptosis, disease mutation, DNA-binding, DNA-binding protein, li-fraumeni syndrome, nuclear protein, p53 DNA-binding domain, phosphorylation, polymorphism, second-site suppressor mutation, superstable mutant, transcription regulation, tumor suppressor, transferase, acetylation, glycoprotein metal-binding, zinc
Deposited on 2005-01-25, released 2005-01-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.217
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Cellular tumor antigen p53
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04637
    • engineered mutation (39)
    • engineered mutation (74)
    • engineered mutation (109)
    • engineered mutation (145)
    • engineered mutation (155)
    • engineered mutation (174)
  Domains in SCOPe 2.05: d2bipa_
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >2bipA (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
  hsvvvpyeppevgsdcttihynymcysscmggmnrspiltiitledssgnllgrdsfevr
  vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >2bipA (A:)
  svpsqktyqgsygfrlgflsvtctyspalnklfcqlaktcpvqlwvdstpppgtrvrama
  iykqsqrmtevvrrcphhercsdglappqhlirvegnlraeylddrntfrhsvvvpyepp
  evgsdcttihynymcysscgmnrspiltiitledssgnllgrdsfevrvcacpgrdrrte
  eenlr