PDB entry 2bfx
View 2bfx on RCSB PDB site
Description: Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Class: transferase
Keywords: transferase, kinase, mitosis, inhibition, transferase complex
Deposited on
2004-12-15, released
2005-05-03
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-05-14, with a file datestamp of
2014-05-09.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.197
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: aurora kinase b-a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2bfxa_ - Chain 'B':
Compound: aurora kinase b-a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2bfxb_ - Chain 'C':
Compound: inner centromere protein a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: inner centromere protein a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2bfxA (A:)
talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
dliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqsk
Sequence, based on observed residues (ATOM records): (download)
>2bfxA (A:)
rkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehqlrreieiq
shlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfmeeladalh
ycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylppemiegkt
hdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgskdliskllr
yhppqrlplkgvmehpwvkansrrvlppvyq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2bfxB (B:)
talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
dliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqsk
Sequence, based on observed residues (ATOM records): (download)
>2bfxB (B:)
talaempkrkftiddfdigrplgkgnvylarekqnkfimalkvlfksqlekegvehqlrr
eieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfmeel
adalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylppem
iegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgskdli
skllryhppqrlplkgvmehpwvkansrrvlppvyqs
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.