PDB entry 2bfm

View 2bfm on RCSB PDB site
Description: leishmania major pteridine reductase 1 in complex with nadp and trimethoprim
Class: oxidoreductase
Keywords: pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase
Deposited on 2004-12-09, released 2005-08-31
The last revision prior to the SCOP 1.73 freeze date was dated 2005-08-31, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.2549
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pteridine reductase 1
    Species: Leishmania major
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bfma1
  • Chain 'B':
    Compound: pteridine reductase 1
    Species: Leishmania major
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bfmb1
  • Chain 'C':
    Compound: pteridine reductase 1
    Species: Leishmania major
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bfmc1
  • Chain 'D':
    Compound: pteridine reductase 1
    Species: Leishmania major
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2bfmd1
  • Heterogens: NDP, TOP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bfmA (A:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfmA (A:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrgdreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvvi
flcsskakyitgtcvkvdggysltra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bfmB (B:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfmB (B:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvvi
flcsskakyitgtcvkvdggysltra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2bfmC (C:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfmC (C:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvataapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadlfg
snaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleglt
rsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyitg
tcvkvdggysltra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2bfmD (D:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfmD (D:)
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadl
fgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleg
ltrsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyi
tgtcvkvdggysltra