PDB entry 2bfc
View 2bfc on RCSB PDB site
Description: reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
Class: oxidoreductase
Keywords: oxidoreductase,ketoacid dehydrogenase,branched-chain,multi-enzyme complex,acylation,oxidative decarboxylation,maple syrup urine disease,thiamine diphosphate,phosphorylation, conformational switch,reactivity
Deposited on
2004-12-06, released
2006-02-16
The last revision prior to the SCOP 1.73 freeze date was dated
2006-02-16, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: 0.14395
AEROSPACI score: 0.6
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 2-oxoisovalerate dehydrogenase alpha subunit
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P12694 (Start-399)
- engineered mutation (112)
- Chain 'B':
Compound: 2-oxoisovalerate dehydrogenase beta subunit
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2bfcb1, d2bfcb2 - Heterogens: K, MN, TZD, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2bfcB (B:)
vahftfqpdpepreygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvgl
rdkygkdrvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryr
sgdlfncgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllscie
dknpciffepkilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasm
akeklgvscevidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecf
lnleapisrvcgydtpfphifepfyipdkwkcydalrkminy
Sequence, based on observed residues (ATOM records): (download)
>2bfcB (B:)
ahfeygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglrdkygkdrvf
ntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrsgdlfncgsl
tirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllsciedknpciffep
kilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasmakeklgvsce
vidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecflnleapisrv
cgydtpfphifepfyipdkwkcydalrkminy