PDB entry 2bcj

View 2bcj on RCSB PDB site
Description: Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
Class: transferase/hydrolase
Keywords: Peripheral membrane complex, protein kinase, RGS domain, WD40 protein, heterotrimeric G protein, TRANSFERASE-HYDROLASE COMPLEX
Deposited on 2005-10-19, released 2005-12-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 3.06 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: G-protein-coupled receptor kinase 2
    Species: Bos taurus [TaxId:9913]
    Gene: GRK2, ADRBK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bcja1, d2bcja2, d2bcja3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bcjb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bcjg_
  • Chain 'Q':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(q) subunit alpha chimera
    Species: , [TaxId:10090]
    Gene: Gnaq
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bcjq1, d2bcjq2
  • Heterogens: MG, ALF, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2bcjA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclkhleeakplvefyeeikkyekleteeerlvcsreifdtyimkellac
    shpfsksaiehvqghlvkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    ktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprapvvelskvpliqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bcjA (A:)
    askkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefye
    eikkyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfq
    pyieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevyg
    crkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkl
    sfildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanillde
    hghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrg
    hspfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqev
    kespffrsldwqmvflqkyppplipprgdtkgiklldsdqelyrnfpltiserwqqevae
    tvfdtinaetdrlearkktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfyl
    fpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqw
    kkelrdayreaqqlvqrvpkmknk
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2bcjB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >2bcjG (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffsail
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bcjG (G:)
    nntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre
    kkff
    

  • Chain 'Q':
    Sequence, based on SEQRES records: (download)
    >2bcjQ (Q:)
    mgctlsaedkaaverskmidrnlredgersrrelkllllgtgesgkstfikqmriihgsg
    ysdedkrgftklvyqniftamqamiramdtlkipykyehnkahaqlvrevdvekvsafen
    pyvdaikslwndpgiqecydrrreyqlsdstkyylndldrvadpsylptqqdvlrvrvpt
    tgiieypfdlqsvifrmvdvggqrserrkwihcfenvtsimflvalseydqvlvesdnen
    rmeeskalfrtiitypwfqnssvilflnkkdlleekimyshlvdyfpeydgpqrdaqaar
    efilkmfvdlnpdsdkiiyshftcatdtenirfvfaavkdtilqlnlkeynlv
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bcjQ (Q:)
    relkllllgtgesgkstfikqmriihgsgysdedkrgftklvyqniftamqamiramdtl
    kipykyehnkahaqlvrevdvekvsafenpyvdaikslwndpgiqecydrrreyqlsdst
    kyylndldrvadpsylptqqdvlrvrvpttgiieypfdlqsvifrmvdvggqrserrkwi
    hcfenvtsimflvalseydqvlvesdnenrmeeskalfrtiitypwfqnssvilflnkkd
    lleekimyshlvdyfpeydgpqrdaqaarefilkmfvdlnpdsdkiiyshftcatdteni
    rfvfaavkdtilqlnlk