PDB entry 2b7d
View 2b7d on RCSB PDB site
Description: Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
Class: blood clotting
Keywords: short hydrogen bond, BLOOD CLOTTING
Deposited on
2005-10-04, released
2006-02-14
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: 0.247
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Coagulation factor VII
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2b7dh_ - Chain 'L':
Compound: Coagulation factor VII
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2b7dl1, d2b7dl2 - Chain 'T':
Compound: tissue factor
Species: Homo sapiens [TaxId:9606]
Gene: F3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2b7dt1, d2b7dt2 - Heterogens: C1B, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>2b7dH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
- Chain 'L':
Sequence, based on SEQRES records: (download)
>2b7dL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipilekrnaskpqgr
Sequence, based on observed residues (ATOM records): (download)
>2b7dL (L:)
qcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgt
krscrchegyslladgvsctptveypcgkipile
- Chain 'T':
Sequence, based on SEQRES records: (download)
>2b7dT (T:)
gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
genycfsvqavipsrtvnrkstdspvecmgqekgefre
Sequence, based on observed residues (ATOM records): (download)
>2b7dT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
dvfgkdliytlsvqavipsrtvnrkstds