PDB entry 2b5i

View 2b5i on RCSB PDB site
Description: cytokine receptor complex
Class: cytokine/cytokine receptor
Keywords: four-helix bundle, Fibronectin domain, CYTOKINE-CYTOKINE RECEPTOR COMPLEX
Deposited on 2005-09-28, released 2005-11-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.225
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2b5ia_
  • Chain 'B':
    Compound: Interleukin-2 receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2RB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14784
      • engineered (16)
      • engineered (44)
    Domains in SCOPe 2.06: d2b5ib1, d2b5ib2
  • Chain 'C':
    Compound: Cytokine receptor common gamma chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31785 (0-End)
      • engineered (19)
    Domains in SCOPe 2.06: d2b5ic1, d2b5ic2
  • Chain 'D':
    Compound: Interleukin-2 receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2RA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2b5id1, d2b5id2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2b5iA (A:)
aptssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcle
eelkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnr
witfcqsiistlt

    Sequence, based on observed residues (ATOM records): (download) 
    >2b5iA (A:)
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqslrprdlisninvivlelkgfmceyadetativeflnrwitfcqsiistlt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2b5iB (B:)
avqgtsqftcfynsraqiscvwsqdgalqdtscqvhawpdrrrwqqtcellpvsqaswac
nlilgapdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhveth
rcnisweisqashyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyef
qvrvkplqgefttwspwsqplafrtkpaalgkdt

    Sequence, based on observed residues (ATOM records): (download) 
    >2b5iB (B:)
sqftcfynsraqiscvwsqtscqvhawpdrrrwqqtcellpvsqaswacnlilgapdsqk
lttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhvethrcnisweisqa
shyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyefqvrvkplqgef
ttwspwsqplafrtkp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2b5iC (C:)
plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
hwsewshpihwgsntsken

    Sequence, based on observed residues (ATOM records): (download) 
    >2b5iC (C:)
plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
hwsewshpihw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2b5iD (D:)
elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgnsshsswdnqcq
ctssatrqttkqvtpqpeeqkerkttemqspmqpvdqaslpghcrepppweneateriyh
fvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlictgemetsqfpgeekpqa
spegrpesetsclvtttdfqiqtemaatmetsiftte

    Sequence, based on observed residues (ATOM records): (download) 
    >2b5iD (D:)
elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctsswdnqcqctssh
crepppweneateriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlic
tg