PDB entry 2b5i

View 2b5i on RCSB PDB site
Description: cytokine receptor complex
Class: cytokine/cytokine receptor
Keywords: four-helix bundle, Fibronectin domain
Deposited on 2005-09-28, released 2005-11-29
The last revision prior to the SCOP 1.73 freeze date was dated 2005-11-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.225
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-2
    Species: HOMO SAPIENS
    Gene: IL2
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2b5ia1
  • Chain 'B':
    Compound: Interleukin-2 receptor beta chain
    Species: HOMO SAPIENS
    Gene: IL2RB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14784
      • engineered (16)
      • engineered (44)
    Domains in SCOP 1.73: d2b5ib1, d2b5ib2
  • Chain 'C':
    Compound: Cytokine receptor common gamma chain
    Species: HOMO SAPIENS
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31785 (0-End)
      • engineered (19)
    Domains in SCOP 1.73: d2b5ic1, d2b5ic2
  • Chain 'D':
    Compound: Interleukin-2 receptor alpha chain
    Species: HOMO SAPIENS
    Gene: IL2RA
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2b5id1, d2b5id2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2b5iA (A:)
    aptssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcle
    eelkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnr
    witfcqsiistlt
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b5iA (A:)
    stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
    leevlnlaqslrprdlisninvivlelkgfmceyadetativeflnrwitfcqsiistlt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2b5iB (B:)
    avqgtsqftcfynsraqiscvwsqdgalqdtscqvhawpdrrrwqqtcellpvsqaswac
    nlilgapdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhveth
    rcnisweisqashyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyef
    qvrvkplqgefttwspwsqplafrtkpaalgkdt
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b5iB (B:)
    sqftcfynsraqiscvwsqtscqvhawpdrrrwqqtcellpvsqaswacnlilgapdsqk
    lttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhvethrcnisweisqa
    shyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyefqvrvkplqgef
    ttwspwsqplafrtkp
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2b5iC (C:)
    plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
    qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
    nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
    hwsewshpihwgsntsken
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b5iC (C:)
    plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
    qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
    nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
    hwsewshpihw
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2b5iD (D:)
    elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgnsshsswdnqcq
    ctssatrqttkqvtpqpeeqkerkttemqspmqpvdqaslpghcrepppweneateriyh
    fvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlictgemetsqfpgeekpqa
    spegrpesetsclvtttdfqiqtemaatmetsiftte
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b5iD (D:)
    elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctsswdnqcqctssh
    crepppweneateriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlic
    tg