PDB entry 2b4y

View 2b4y on RCSB PDB site
Description: Crystal Structure of Human Sirtuin homolog 5
Class: hydrolase
Keywords: histone deacetylase, Structural Genomics, Structural Genomics Consortium, Structural Genomics Consortium, SGC
Deposited on 2005-09-27, released 2006-02-28
The last revision prior to the SCOP 1.75 freeze date was dated 2006-02-28, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.185
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent deacetylase sirtuin-5
    Species: HOMO SAPIENS
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (Start-270)
      • modified residue (8)
      • modified residue (77)
      • modified residue (227)
    Domains in SCOP 1.75: d2b4ya1
  • Chain 'B':
    Compound: NAD-dependent deacetylase sirtuin-5
    Species: HOMO SAPIENS
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (Start-270)
      • modified residue (8)
      • modified residue (77)
      • modified residue (227)
    Domains in SCOP 1.75: d2b4yb1
  • Chain 'C':
    Compound: NAD-dependent deacetylase sirtuin-5
    Species: HOMO SAPIENS
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (Start-270)
      • modified residue (8)
      • modified residue (77)
      • modified residue (227)
    Domains in SCOP 1.75: d2b4yc1
  • Chain 'D':
    Compound: NAD-dependent deacetylase sirtuin-5
    Species: HOMO SAPIENS
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (Start-270)
      • modified residue (8)
      • modified residue (77)
      • modified residue (227)
    Domains in SCOP 1.75: d2b4yd1
  • Heterogens: ZN, APR, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2b4yA (A:)
gsarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplaf
ahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagt
knlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeag
cggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpv
aefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4yA (A:)
psssmadfrkffakakhiviisgagvsaesgvgywrkwqaqdlatplafahnpsrvwefy
hyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihgslf
ktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrphvvw
fgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntettpat
nrfrfhfqgpcgttlpeala

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2b4yB (B:)
gsarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplaf
ahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagt
knlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeag
cggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpv
aefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4yB (B:)
psssmadfrkffakakhiviisgagvsaesgvptgywrkwqaqdlatplafahnpsrvwe
fyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihgs
lfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrphv
vwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntettp
atnrfrfhfqgpcgttlpeala

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2b4yC (C:)
gsarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplaf
ahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagt
knlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeag
cggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpv
aefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4yC (C:)
psssmadfrkffakakhiviisgagvsaesgvptfrywrkwqaqdlatplafahnpsrvw
efyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihg
slfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrph
vvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntett
patnrfrfhfqgpcgttlpeala

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2b4yD (D:)
gsarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplaf
ahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagt
knlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeag
cggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpv
aefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4yD (D:)
psssmadfrkffakakhiviisgagvsaesgvptfywrkwqaqdlatplafahnpsrvwe
fyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihgs
lfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrphv
vwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntettp
atnrfrfhfqgpcgttlpeala