PDB entry 2b4t

View 2b4t on RCSB PDB site
Description: Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom resolution reveals intriguing extra electron density in the active site
Class: oxidoreductase
Keywords: STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, GAPDH, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, Structural Genomics of Pathogenic Protozoa Consortium, SGPP, OXIDOREDUCTASE
Deposited on 2005-09-26, released 2005-10-04
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.176
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'O':
    Compound: glyceraldehyde-3-phosphate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PF14_0598
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8T6B1
      • engineered (343)
    Domains in SCOPe 2.03: d2b4to1, d2b4to2
  • Chain 'P':
    Compound: glyceraldehyde-3-phosphate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PF14_0598
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8T6B1
      • engineered (343)
    Domains in SCOPe 2.03: d2b4tp1, d2b4tp2
  • Chain 'Q':
    Compound: glyceraldehyde-3-phosphate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PF14_0598
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8T6B1
      • engineered (343)
    Domains in SCOPe 2.03: d2b4tq1, d2b4tq2
  • Chain 'R':
    Compound: glyceraldehyde-3-phosphate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PF14_0598
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8T6B1
      • engineered (343)
    Domains in SCOPe 2.03: d2b4tr1, d2b4tr2
  • Heterogens: NAD, AES, HOH

PDB Chain Sequences:

  • Chain 'O':
    Sequence, based on SEQRES records: (download)
    >2b4tO (O:)
    mahhhhhhmaatklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsv
    hgqfpcevthadgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshl
    kggakkvimsappkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiv
    eglmttvhastanqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngklt
    gvafrvpigtvsvvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhd
    nrssifdmkaglalndnffklvswydnewgysnrvldlavhitts
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4tO (O:)
    tklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsvhgqfpcevtha
    dgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshlkggakkvimsa
    ppkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiveglmttvhast
    anqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngkltgvafrvpigtv
    svvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhdnrssifdmkag
    lalndnffklvswydnewgysnrvldlavhitt
    

  • Chain 'P':
    Sequence, based on SEQRES records: (download)
    >2b4tP (P:)
    mahhhhhhmaatklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsv
    hgqfpcevthadgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshl
    kggakkvimsappkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiv
    eglmttvhastanqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngklt
    gvafrvpigtvsvvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhd
    nrssifdmkaglalndnffklvswydnewgysnrvldlavhitts
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4tP (P:)
    tklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsvhgqfpcevtha
    dgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshlkggakkvimsa
    ppkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiveglmttvhast
    anqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngkltgvafrvpigtv
    svvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhdnrssifdmkag
    lalndnffklvswydnewgysnrvldlavhitt
    

  • Chain 'Q':
    Sequence, based on SEQRES records: (download)
    >2b4tQ (Q:)
    mahhhhhhmaatklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsv
    hgqfpcevthadgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshl
    kggakkvimsappkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiv
    eglmttvhastanqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngklt
    gvafrvpigtvsvvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhd
    nrssifdmkaglalndnffklvswydnewgysnrvldlavhitts
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4tQ (Q:)
    tklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsvhgqfpcevtha
    dgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshlkggakkvimsa
    ppkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiveglmttvhast
    anqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngkltgvafrvpigtv
    svvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhdnrssifdmkag
    lalndnffklvswydnewgysnrvldlavhitt
    

  • Chain 'R':
    Sequence, based on SEQRES records: (download)
    >2b4tR (R:)
    mahhhhhhmaatklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsv
    hgqfpcevthadgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshl
    kggakkvimsappkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiv
    eglmttvhastanqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngklt
    gvafrvpigtvsvvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhd
    nrssifdmkaglalndnffklvswydnewgysnrvldlavhitts
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4tR (R:)
    tklgingfgrigrlvfraafgrkdievvaindpfmdlnhlcyllkydsvhgqfpcevtha
    dgflligekkvsvfaekdpsqipwgkcqvdvvcestgvfltkelasshlkggakkvimsa
    ppkddtpiyvmginhhqydtkqlivsnascttnclaplakvindrfgiveglmttvhast
    anqlvvdgpskggkdwragrcalsniipastgaakavgkvlpelngkltgvafrvpigtv
    svvdlvcrlqkpakyeevaleikkaaegplkgilgytedevvsqdfvhdnrssifdmkag
    lalndnffklvswydnewgysnrvldlavhitt