PDB entry 2b4c

View 2b4c on RCSB PDB site
Description: Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Class: Viral protein/Immune system
Keywords: HIV-1, gp120, JRFL, V3, X5, CD4 induced antibody, Viral protein-Immune system COMPLEX
Deposited on 2005-09-23, released 2005-11-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.319
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2b4cc1, d2b4cc2
  • Chain 'G':
    Compound: Envelope glycoprotein
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • GB AAB05604 (5-48)
    • GB AAB05604 (52-343)
    Domains in SCOPe 2.06: d2b4cg1
  • Chain 'H':
    Compound: anti-HIV-1 gp120 immunoglobulin X5 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2B4C (Start-234)
    Domains in SCOPe 2.06: d2b4ch1, d2b4ch2
  • Chain 'L':
    Compound: anti-HIV-1 gp120 immunoglobulin X5 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2B4C (0-214)
    Domains in SCOPe 2.06: d2b4cl1, d2b4cl2
  • Heterogens: NAG, NDG, XYL, SO4

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2b4cC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4cC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidiv
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >2b4cG (G:)
    garsevvlenvtehfnmwkndmveqmqediislwdqslkpcvkltplcvgagscdtsvit
    qacpkisfepipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqllln
    gslaeeevvirsdnftnnaktiivqlkesveinctrpnqntrksihigpgrafyttgeii
    gdirqahcnisrakwndtlkqiviklreqfenktivfnhssggdpeivmhsfncggeffy
    cnsaqlfnstwnnntegsnntegntitlpcrikqiinmwqevgkamyappirgqircssn
    itgllltrdgginengteifrpgggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4cG (G:)
    vvlenvtehfnmwkndmveqmqediislwdqslkpcvkltplcvgagscdtsvitqacpk
    isfepipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqlllngslae
    eevvirsdnftnnaktiivqlkesveinctrpnqntrksihigpgrafyttgeiigdirq
    ahcnisrakwndtlkqiviklreqfenktivfnhssggdpeivmhsfncggeffycnsaq
    lfnstwnnntegsnntegntitlpcrikqiinmwqevgkamyappirgqircssnitgll
    ltrdgginengteifrpgggdmrdnwrselykykvvkie
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2b4cH (H:)
    evqlleqsgaevkkpgssvqvsckasggtfsmygfnwvrqapghglewmggiipifgtsn
    yaqkfrgrvtftadqatstaymeltnlrsddtavyycardfgpdwedgdsydgsgrgffd
    fwgqgtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
    gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b4cH (H:)
    qlleqsgaevkkpgssvqvsckasggtfsmygfnwvrqapghglewmggiipifgtsnya
    qkfrgrvtftadqatstaymeltnlrsddtavyycardfgpdwedgdsydgsgrgffdfw
    gqgtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgv
    htfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2b4cL (L:)
    elvltqspgtlslsageratlscrasqsvssgslawyqqkpgqaprlliygastratgip
    drfsgsgsgtdftltigrlepedlavyycqqygtspytfgqgtkleikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsrdstyslgstl
    tlskadyekhkvyacevthqglsspvtksfnrgec