PDB entry 2b2x

View 2b2x on RCSB PDB site
Description: VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab
Class: immune system
Keywords: computational design, antibody-antigen complex, Immune system
Deposited on 2005-09-19, released 2006-04-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrin alpha-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Itga1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614
      • engineered (92-94)
      • engineered (97)
    Domains in SCOPe 2.07: d2b2xa_
  • Chain 'B':
    Compound: integrin alpha-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Itga1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614
      • engineered (92-94)
      • engineered (97)
    Domains in SCOPe 2.07: d2b2xb_
  • Chain 'H':
    Compound: Antibody AQC2 Fab
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2B2X (0-End)
  • Chain 'I':
    Compound: Antibody AQC2 Fab
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2B2X (0-End)
  • Chain 'L':
    Compound: Antibody AQC2 Fab
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2B2X (0-End)
    Domains in SCOPe 2.07: d2b2xl1, d2b2xl2
  • Chain 'M':
    Compound: Antibody AQC2 Fab
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2B2X (0-End)
    Domains in SCOPe 2.07: d2b2xm1, d2b2xm2
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2b2xA (A:)
    gsvsptfqvvnsfapvqecstqldivivldgsnsiypwesviaflndllkrmdigpkqtq
    vgivqygenvthefnlnkyssteevlvaankivqrggrqtmtalgidtarkeaftearga
    rrgvkkvmvivtdgeshdnyrlkqviqdcedeniqrfsiailghynrgnlstekfveeik
    siaseptekhffnvsdelalvtivkalgerifalealerphrd
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b2xA (A:)
    qldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkyss
    teevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdnyr
    lkqviqdcedeniqrfsiailghynlstekfveeiksiaseptekhffnvsdelalvtiv
    kalgerif
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2b2xB (B:)
    gsvsptfqvvnsfapvqecstqldivivldgsnsiypwesviaflndllkrmdigpkqtq
    vgivqygenvthefnlnkyssteevlvaankivqrggrqtmtalgidtarkeaftearga
    rrgvkkvmvivtdgeshdnyrlkqviqdcedeniqrfsiailghynrgnlstekfveeik
    siaseptekhffnvsdelalvtivkalgerifalealerphrd
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b2xB (B:)
    ldivivldgsnsiypwesviaflndllkrgpkqtqvgivqygenvthefnlnkyseevlv
    aankivqrggrqtmtalgidtarkeafteargarkvmvivtdgeshdnyrlkqviqdced
    eniqrfsiailghystekfveeiksiaseptekhffnvsdelalvtivkalgerif
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2b2xL (L:)
    qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
    fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
    seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
    tkdeyerhnsytceathktstspivksfnrnec
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b2xL (L:)
    qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
    fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
    seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
    tkdeyerhnsytceathktstspivksfnr
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >2b2xM (M:)
    qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
    fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
    seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
    tkdeyerhnsytceathktstspivksfnrnec
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b2xM (M:)
    qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
    fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
    seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
    tkdeyerhnsytceathktstspivksfnr