PDB entry 2az5

View 2az5 on RCSB PDB site
Description: Crystal Structure of TNF-alpha with a small molecule inhibitor
Class: cytokine
Keywords: TNF-alpha trimer disruption by binding of a small molecule inhibitor, CYTOKINE
Deposited on 2005-09-09, released 2005-11-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.227
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2az5a_
  • Chain 'B':
    Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2az5b_
  • Chain 'C':
    Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2az5c_
  • Chain 'D':
    Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2az5d_
  • Heterogens: 307, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2az5A (A:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
    drlsaeinrpdyldfaesgqvyfgiial
    

    Sequence, based on observed residues (ATOM records): (download)
    >2az5A (A:)
    dkpvahvvanpqaegqlqwlnllangvelrdnqlvvpseglyliysqvlfkgqgcpsthv
    llthtisriavsyqtkvnllsaikspcpwyepiylggvfqlekgdrlsaeinrpdyldfa
    esgqvyfgiial
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2az5B (B:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
    drlsaeinrpdyldfaesgqvyfgiial
    

    Sequence, based on observed residues (ATOM records): (download)
    >2az5B (B:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqrkpwyepiylggvfqlekgdrlsaein
    rpdyldfaesgqvyfgiial
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2az5C (C:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
    drlsaeinrpdyldfaesgqvyfgiial
    

    Sequence, based on observed residues (ATOM records): (download)
    >2az5C (C:)
    dkpvahvvanpqaegqlqwlnllangvelrdnqlvvpseglyliysqvlfkgqgcpsthv
    llthtisriavtkvnllsaikspcpwyepiylggvfqlekgdrlsaeinrpdyldfaesg
    qvyfgiial
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2az5D (D:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
    drlsaeinrpdyldfaesgqvyfgiial
    

    Sequence, based on observed residues (ATOM records): (download)
    >2az5D (D:)
    dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
    psthvllthtisriavsyqtkvnllsaikspcqrakpwyepiylggvfqlekgdrlsaei
    nrpdyldfaesgqvyfgiial