PDB entry 2az5
View 2az5 on RCSB PDB site
Description: Crystal Structure of TNF-alpha with a small molecule inhibitor
Class: cytokine
Keywords: TNF-alpha trimer disruption by binding of a small molecule inhibitor, CYTOKINE
Deposited on
2005-09-09, released
2005-11-29
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.227
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2az5a_ - Chain 'B':
Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2az5b_ - Chain 'C':
Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2az5c_ - Chain 'D':
Compound: Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2az5d_ - Heterogens: 307, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2az5A (A:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2az5A (A:)
dkpvahvvanpqaegqlqwlnllangvelrdnqlvvpseglyliysqvlfkgqgcpsthv
llthtisriavsyqtkvnllsaikspcpwyepiylggvfqlekgdrlsaeinrpdyldfa
esgqvyfgiial
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2az5B (B:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2az5B (B:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqrkpwyepiylggvfqlekgdrlsaein
rpdyldfaesgqvyfgiial
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2az5C (C:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2az5C (C:)
dkpvahvvanpqaegqlqwlnllangvelrdnqlvvpseglyliysqvlfkgqgcpsthv
llthtisriavtkvnllsaikspcpwyepiylggvfqlekgdrlsaeinrpdyldfaesg
qvyfgiial
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2az5D (D:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2az5D (D:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqrakpwyepiylggvfqlekgdrlsaei
nrpdyldfaesgqvyfgiial