PDB entry 2av1
View 2av1 on RCSB PDB site
Description: Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
Class: immune system
Keywords: X-ray, TAX peptide, MHC, mutated HLA-A2, E63Q, K66A
Deposited on
2005-08-29, released
2005-10-18
The last revision prior to the SCOP 1.73 freeze date was dated
2005-10-18, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.177
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: HLA class I histocompatibility antigen, A-2 alpha chain
Species: HOMO SAPIENS
Gene: HLA-A, HLAA
Database cross-references and differences (RAF-indexed):
- Uniprot P01892 (0-274)
- engineered (62)
- engineered (65)
Domains in SCOP 1.73: d2av1a1, d2av1a2 - Chain 'B':
Compound: Beta-2-microglobulin
Species: HOMO SAPIENS
Gene: B2M
Database cross-references and differences (RAF-indexed):
- Uniprot P61770 (1-99)
- initiating methionine (0)
Domains in SCOP 1.73: d2av1b1 - Chain 'C':
Compound: Trans-activating transcriptional regulatory peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: HLA class I histocompatibility antigen, A-2 alpha chain
Species: HOMO SAPIENS
Gene: HLA-A, HLAA
Database cross-references and differences (RAF-indexed):
- Uniprot P01892 (0-274)
- engineered (62)
- engineered (65)
Domains in SCOP 1.73: d2av1d1, d2av1d2 - Chain 'E':
Compound: Beta-2-microglobulin
Species: HOMO SAPIENS
Gene: B2M
Database cross-references and differences (RAF-indexed):
- Uniprot P61770 (1-99)
- initiating methionine (0)
Domains in SCOP 1.73: d2av1e1 - Chain 'F':
Compound: Trans-activating transcriptional regulatory peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: SCN, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2av1A (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgqtravkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2av1B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'C':
No sequence available.
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>2av1D (D:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgqtravkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>2av1E (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'F':
No sequence available.