PDB entry 2av1

View 2av1 on RCSB PDB site
Description: Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
Class: immune system
Keywords: TAX peptide, MHC, mutated HLA-A2, E63Q, K66A, IMMUNE SYSTEM
Deposited on 2005-08-29, released 2005-10-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.177
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A, HLAA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
    • engineered (62)
    • engineered (65)
  Domains in SCOPe 2.08: d2av1a1, d2av1a2
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61770 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.08: d2av1b2, d2av1b3
• Chain 'C':
  Compound: Trans-activating transcriptional regulatory peptide
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P14079 (0-8)
• Chain 'D':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A, HLAA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
    • engineered (62)
    • engineered (65)
  Domains in SCOPe 2.08: d2av1d1, d2av1d2
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61770 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.08: d2av1e2, d2av1e3
• Chain 'F':
  Compound: Trans-activating transcriptional regulatory peptide
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P14079 (0-8)
• Heterogens: SCN, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2av1A (A:)
  gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
  dgqtravkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
  kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
  rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
  fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2av1B (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2av1D (D:)
  gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
  dgqtravkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
  kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
  rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
  fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2av1E (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.