PDB entry 2aox

View 2aox on RCSB PDB site
Description: Histamine Methyltransferase (Primary Variant T105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine
Class: transferase
Keywords: classic methyltransferase fold, protein-drug complex
Deposited on 2005-08-14, released 2005-09-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.12 Å
R-factor: 0.229
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2aoxa_
  • Chain 'B':
    Compound: Histamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2aoxb_
  • Heterogens: THA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aoxA (A:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aoxA (A:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aoxB (B:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aoxB (B:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea