PDB entry 2aov

View 2aov on RCSB PDB site
Description: Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine
Class: transferase
Keywords: classic methyltransferase fold, protein-drug complex
Deposited on 2005-08-14, released 2005-09-13
The last revision prior to the SCOP 1.73 freeze date was dated 2005-10-18, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: 0.211
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: HNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2aova1
  • Chain 'B':
    Compound: Histamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: HNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2aovb1
  • Heterogens: 4DI, C2M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aovA (A:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aovA (A:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aovB (B:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aovB (B:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea