PDB entry 2aot

View 2aot on RCSB PDB site
Description: Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine
Class: transferase
Keywords: classic methyltransferase fold, protein-drug complex
Deposited on 2005-08-14, released 2005-09-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.221
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HNMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50135 (Start-291)
      • modified residue (81)
      • modified residue (216)
      • modified residue (247)
    Domains in SCOPe 2.06: d2aota_
  • Chain 'B':
    Compound: Histamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HNMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50135 (Start-291)
      • modified residue (81)
      • modified residue (216)
      • modified residue (247)
    Domains in SCOPe 2.06: d2aotb_
  • Heterogens: 2PM, SAH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2aotA (A:)
    massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
    ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
    seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
    klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
    wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aotA (A:)
    mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
    eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
    srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
    kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
    tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2aotB (B:)
    massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
    ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
    seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
    klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
    wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aotB (B:)
    mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
    eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
    srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
    kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
    tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea