PDB entry 2ant

View 2ant on RCSB PDB site
Description: the 2.6 a structure of antithrombin indicates a conformational change at the heparin binding site
Class: serpin
Keywords: serpin, heparin, inhibitor
Deposited on 1997-01-28, released 1997-06-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.217
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: antithrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2anti_
  • Chain 'L':
    Compound: antithrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2antl_
  • Heterogens: NAA, HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >2antI (I:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2antI (I:)
    hgspvdictakprdipmnpmciyrspekkatnrrvwelskansrfattfyqhladskndn
    dniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrk
    ankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnk
    tegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmy
    qegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldelee
    mmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkafl
    evneegseaaastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcvk
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2antL (L:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2antL (L:)
    ictakdipmnpmciyrsatnrrvwelskansrfattfyqhladskndndniflsplsist
    afamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvsanr
    lfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvipse
    aineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrvae
    gtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfri
    edgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneegseaaas
    tavviagrslnrpflvfirevplntiifmgrvanpcvk