PDB entry 2an4
View 2an4 on RCSB PDB site
Description: Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine
Class: transferase
Keywords: methyltransferase, substrate structure, S-adenosyl-L-methionine, adrenaline synthesis, TRANSFERASE
Deposited on
2005-08-11, released
2006-03-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.229
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Phenylethanolamine N-methyltransferase
Species: Homo sapiens [TaxId:9606]
Gene: PNMT
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2an4a2, d2an4a3 - Chain 'B':
Compound: Phenylethanolamine N-methyltransferase
Species: Homo sapiens [TaxId:9606]
Gene: PNMT
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2an4b2, d2an4b3 - Heterogens: PO4, SAH, OTR, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2an4A (A:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2an4A (A:)
asayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsgrtlidigsgpt
vyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacliegkgecwqdk
erqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlasfqraldhitt
llrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdlrtyimpahlq
tgvddvkgvffawaqkvg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2an4B (B:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2an4B (B:)
pdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsgr
tlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacli
egkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlas
fqraldhittllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdl
rtyimpahlqtgvddvkgvffawaqkvg