PDB entry 2an3

View 2an3 on RCSB PDB site
Description: Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol.
Class: transferase
Keywords: methyltransferase, substrate structure, S-adenosyl-L-methionine, adrenaline synthesis
Deposited on 2005-08-11, released 2006-03-14
The last revision prior to the SCOP 1.73 freeze date was dated 2006-03-14, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.217
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phenylethanolamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: PNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2an3a1
  • Chain 'B':
    Compound: Phenylethanolamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: PNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2an3b1
  • Heterogens: SAH, CTL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2an3A (A:)
    msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
    laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
    fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
    afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
    ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2an3A (A:)
    vasayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsgrtlidigsgp
    tvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacliegkgecwqd
    kerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlasfqraldhit
    tllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdlrtyimpahl
    qtgvddvkgvffawaqkv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2an3B (B:)
    msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
    laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
    fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
    afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
    ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2an3B (B:)
    apdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsg
    rtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacl
    iegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdla
    sfqraldhittllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrd
    lrtyimpahlqtgvddvkgvffawaqkvg